MUSE (Multi Unit Spectroscopic Explorer) is a 2nd generation Integral Field facility for the VLT. With a field of view of 1x1 arcmin, fine sampling, intermediate spectral resolution and large spectral coverage in the visible, it uses a complex image slicer, twenty-four parallel spectrographs and a large detector area. In addition, MUSE is conceived to work assisted by the Adaptive Optics Facility (AOF), which will enhance notably its performance. MUSE is the result of ten years of design and development by the MUSE consortium — headed by the Centre de Recherche Astrophysique de Lyon, France and the partner institutes Leibniz-Institut für Astrophysik Potsdam (AIP, Germany),  Institut für Astrophysik Göttingen (IAG, Germany),  Institute for Astronomy ETH Zurich (Switzerland), L'Institut de Recherche en Astrophysique et Planétologie (IRAP, France), Nederlandse Onderzoekschool voor de Astronomie (NOVA, the Netherlands) and ESO.
MUSE has been successfully installed on ESO’s Very Large Telescope (VLT). In this talk it will be presented the instrument, its design and challenges, the integration (both in Europe and Paranal), the first light and first commissioning results.