We discuss how a wide field imager with very high spatial resolution on a relatively small telescope but located in an observing site with very good seeing might constrain the fraction of binary stars in Galactic globular clusters. We also mention the role that the new data might play in investigating advanced evolutionary phases of low-mass stars. Moreover, we discuss the role that an Extremely Large Telescope might have on the longstanding problem of cosmic distances and stellar populations. In particular, we discuss the impact that the detection of Cepheids in galaxies at the distance of the Coma cluster and of RR Lyrae stars in galaxies at the distance of the Virgo cluster might have on the calibration of secondary distance indicators.