To be able to detect a biosphere in an extrasolar planet, life in that planet should have been able to alter the original composition of the planetary atmosphere. In this way, an external observer could detect the chemical disequilibrium introduced by living organisms in the planet. The earthshine technique has allowed us to determine the best disk-integrated planetary features that we could use to find life in an exoplanet similar to Earth. Different observing methods have been investigated. In this poster, we summarize the scientific goals that could be reached using a variety of observational methods.