The High Angular Resolution Monolithic Optical and Near-infrared Integral field spectrograph (HARMONI) is a first generation instrument designed for the Extremely Large Telescope (ELT). HARMONI offers operational versatility, enabling both seeing-limited (NOAO) operation and compensation for atmospheric optical turbulence using two systems: Single Conjugate Adaptive Optics (SCAO), with high-contrast capabilities, and Laser Tomography Adaptive Optics (LTAO). With four spatial scale options ranging from 60 to 4 mas and eleven gratings providing resolving powers from R ~ 3200 to R ~ 18000 across a broad spectral range from 470 nm to 2450 nm, HARMONI supports a wide and diverse range of scientific programs. The ongoing development of the HARMONI instrument is progressing towards Final Design Reviews, representing a significant milestone in its journey towards scientific exploration, and paving the way for groundbreaking research endeavors. This talk aims to encourage, particularly young researchers, to consider programs focused on Active Galactic Nuclei (AGN)-related topics, with the goal of maximizing the scientific impact of HARMONI in AGN and galaxy evolution studies. It will provide a comprehensive overview of HARMONI, emphasizing its key features and capabilities in the context of galaxy evolution and nuclear activity across cosmic time.