We have measured the transmission spectrum of the extremely inflated hot Jupiter WASP-52b using simultaneous photometric observations in Sloan Digital Sky Survey u', g' and a filter centred on the sodium doublet (Na I) with the ULTRACAM instrument mounted on the 4.2-m William Herschel Telescope. We find that Rayleigh scattering is not the dominant source of opacity within the planetary atmosphere and find a transmission spectrum more consistent with wavelength-independent opacity such as from clouds. We detect an in-transit anomaly that we attribute to the presence of stellar activity and find that this feature can be more simply modelled as a bright region on the stellar surface akin to solar faculae rather than spots. A spot model requires a significantly larger planet/star radius ratio than that found in previous studies. Our results highlight the precision that can be achieved by ground-based photometry with errors in the scaled planetary radii of less than one atmospheric scale height, comparable to Hubble Space Telescope observations.