We present in this contribution our set of multiwavelength synthesis models including the evolution of single and binary stars. The main results we have obtained can be summarized as follows: (a) massive close-binary systems will start to experience mass transfer episodes after the first 4 Myr of the starburst evolution; (b) as a result of these mass transfer processes, stars of relatively low initial mass can loose completely their envelope and become a WR. In this way, the formation of WR stars is extended over longer than 15 Myr, and does not stop at 6 Myr as predicted by models including only single stars; (c) WR stars can thus be coeval with red supergiants, which peak at around 10 Myr for solar metallicities; (d) the accretion of mass will originate relatively massive stars at ages for which they should have already disappeared; these stars, together with the WR stars formed in rather evolved clusters, increase the production of ionizing photons, so that the H$\beta$ equivalent width will not drop as rapidly as predicted by models considering only individual stars; and (e) the mass transfer to compact companions will produce an additional source of high-energy radiation in the form of high-mass X-ray binaries, not predicted either by standard synthesis models.