In the last decade we have explored the cosmic depths and found a statistically significant number of galaxies well into the Epoch of Reionization. However, our physical knowledge of these pristine objects remains very scant. Investigating the internal structure, interstellar medium and evolution of early galaxies is the next challenge to understand key processes as the cosmic history of baryons, feedback, reionization and metal enrichment of the intergalactic medium, This ambitious plan can be tackled by combining a new generation of physically-rich, high resolution, zoom simulations with data in the sub-mm bands provided by ALMA. This approach will be soon strengthened by the forthcoming JWST power. I will review the present status and the open questions in the field.