I will provide highlights of work at the Space Telescope Science Institute (STScI), which provides science and operations support for NASA's space missions, delivers added value to data archives, and engages the public in the corresponding scientific results. We are preparing for continuing operations of the Hubble Space Telescope through 2025, looking forward to the launch of the James Webb Space Telescope, and contributing to the development of the Wide Field Infrared Survey Telescope. Staff at STScI are also advancing technology and scientific concepts for future flagship space missions.