We present new medium-band uvby Strömgren and broadband VI photometry for the central regions of the globular cluster ω Cen. From this photometry we have obtained differential reddening estimates relative to two other globular clusters (M13 and NGC 288) using a metallicity-independent, reddening-free temperature index, [c]≡(u-v)-(v-b)-0.2(b-y), for hot horizontal-branch (HB) stars (Teff>=8500 K). We estimate color excesses of these hot HB stars using optical and near-infrared colors, and we find clumpy extinction variations of almost a factor of 2 within the area of the cluster core. In particular, the greatest density of more highly reddened objects appears to be shifted along the right ascension axis when compared with less reddened ones. These findings complicate photometric efforts to investigate the star formation history of ω Cen. Based in part on observations collected with the Danish and New Technology Telescopes, operated at ESO La Silla.